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1

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Cheng Yung-Chi, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1973

Language:

english

File:

PDF, 483 KB

english, 1973

2

A novel intramolecular hydrogen bond in the crystal structure of 5-hydroxymethyl-2'-deoxyuridine, an antiviral and antineoplastic nucleoside. Conformational analysis of the deoxyribose ring

Birnbaum, George I., Deslauriers, Roxanne, Lin, Tai Shun, Shiau, George T., Prusoff, William H.

Journal:

Journal of the American Chemical Society

Year:

1980

Language:

english

File:

PDF, 708 KB

english, 1980

3

Synthesis and biological activities of iododeoxyuridine, an analog of thymidine

William H. Prusoff

Journal:

Biochimica et Biophysica Acta

Year:

1959

Language:

english

File:

PDF, 121 KB

english, 1959

4

Design of Anti-HIV Compounds from Nucleoside to Nucleoside 5-Triphosphate Analogs. Problems and Perspectives

Kukhanova, Marina, Krayevsky, Alexander, Prusoff, William, Cheng, Yung-Chi

Journal:

Current Pharmaceutical Design

Year:

2000

Language:

english

File:

PDF, 100 KB

english, 2000

5

Synthesis of 3′-CTNU radiolabelled with 14C in the alkylating moiety and 3H in the carbamoylating moiety

William F. Brubaker Jr., William H. Prusoff

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1985

Language:

english

File:

PDF, 480 KB

english, 1985

6

Synthesis of [2-14C] 3′-deoxythymidin-2′ -ENE (d4T) and [5–125I] 3′ -azido-2′, 3′-dideoxy-5-iodouridine: Potent inhibitors of human immunodeficiency virus (HIV-1)

Tai-Shun Lin, You-Song Gao, E. Michael August, He-Ying Qian, William H. Prusoff

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1989

Language:

english

File:

PDF, 235 KB

english, 1989

7

Syntheses of [2-14C] 2,5′-anhydro-3′-azido-3′-deoxythymidine and [2-14C] 2,5′-anhydro-3′-azido-2′,3′-dideoxy-5-iodouridine: Inhibitors of human immunodeficiency virus (HIV-1)

Tai-Shun Lin, Mao-Chin Liu, E. Michael August, Evelyn M. Birks, William H. Prusoff

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1991

Language:

english

File:

PDF, 300 KB

english, 1991

8

A new rapid assay for measuring deoxycytidylate- and deoxythymidylate-kinase activities

Yung-Chi Cheng, William H. Prusoff

Journal:

Analytical Biochemistry

Year:

1974

Language:

english

File:

PDF, 333 KB

english, 1974

9

Comparative effects of 5′-amino-5′-deoxythymidine, a new 3ntiviral agent, and 5-iodo-2′-deoxyuridine on the immune response of mice. No immunosuppression with 5′-amino-5′-deoxythymidine

James A. Bennett, Paul E. Savoca, Tai-Shun Lin, William H. Prusoff

Journal:

International Journal of Immunopharmacology

Year:

1982

Language:

english

File:

PDF, 717 KB

english, 1982

10

An improved synthesis of 6-azathymidine

George T. Shiau, William H. Prusoff

Journal:

Carbohydrate Research

Year:

1978

Language:

english

File:

PDF, 240 KB

english, 1978

11

Synthesis and properties of boron and silicon substituted uracil or 2′-deoxyuridine

Raymond F. Schinazi, William H. Prusoff

Journal:

Tetrahedron Letters

Year:

1978

Language:

english

File:

PDF, 201 KB

english, 1978

12

Incorporation of 5-Iodo-2′-Deoxyuridine into Bacteriophage T1 as Related to Ultra-Violet Sensitization or Protection

RUPP, W. DEAN, PRUSOFF, WILLIAM H.

Journal:

Year:

1964

File:

PDF, 329 KB

1964

13

Anti-Viral Activity of Azathymidine and Uracil Methyl Sulphone

SEKELY, LEA, PRUSOFF, WILLIAM H.

Journal:

Year:

1966

File:

PDF, 250 KB

1966

14

The effect of the nitrosourea analog of thymidine, 3′-[3-(2-chloroethyl)-3-nitrosoureido]-3′-deoxythymidine, on Escherichia coli thymidine kinase

Ming S. Chen, Tai-Shun Lin, William H. Prusoff

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1980

Language:

english

File:

PDF, 326 KB

english, 1980

15

Regulation of thymidine kinase activity by 5-iodo-2'-deoxyuridine 5'-triphosphate and deoxythymidine 5'-triphosphate

William H. Prusoff, Pauline K. Chang

Journal:

Chemico-Biological Interactions

Year:

1970

Language:

english

File:

PDF, 1.40 MB

english, 1970

16

The effect of 5-Iodouracil on the growth and biosynthetic processes of bacteriophage T4td8 in the absence of light

Daniel M. Byrd, William H. Prusoff

Journal:

Chemico-Biological Interactions

Year:

1976

Language:

english

File:

PDF, 1.19 MB

english, 1976

17

Early nucleoside reverse transcriptase inhibitors for the treatment of HIV: A brief history of stavudine (D4T) and its comparison with other dideoxynucleosides

John C. Martin, Michael J.M. Hitchcock, Erik De Clercq, William H. Prusoff

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 242 KB

english, 2010

18

Inhibition of HIV-1 protease by a boron-modified polypeptide

Arman D Pivazyan, Donald S Matteson, Levente Fabry-Asztalos, Rajendra P Singh, Pin-fang Lin, Wade Blair, Kenny Guo, Brett Robinson, William H Prusoff

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 407 KB

english, 2000

19

THE RELATION OF ANTIVIRAL ACTIVITY OF IUdR TO GENE FUNCTION IN PHAGE

Barry Goz, William H. Prusoff

Journal:

Annals of the New York Academy of Sciences

Year:

1970

Language:

english

File:

PDF, 497 KB

english, 1970

20

SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NOVEL ANALOGS OF THYMIDINE

Yung-Chi Cheng, John P. Neenan, Barry Goz, David C. Ward, William H. Prusoff

Journal:

Annals of the New York Academy of Sciences

Year:

1975

Language:

english

File:

PDF, 1.64 MB

english, 1975

21

COMPARISON OF THE LETHAL EFFECT OF 5-IODOURACIL INCORPORATED INTO BACTERIOPHAGE T4 IN THE PRESENCE AND ABSENCE OF NEAR-VISIBLE LIGHT

Daniel M. Byrd, Barry Goz, William H. Prusoff

Journal:

Photochemistry and Photobiology

Year:

1975

Language:

english

File:

PDF, 565 KB

english, 1975

22

Photosensitivity of 6-azathymine and its effect on the formation of photoproducts of thymine and cytosine

Helge L. Günther, William H. Prusoff

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Year:

1967

Language:

english

File:

PDF, 482 KB

english, 1967

23

Protective effect of 6-azathymine and 6-azauracil against the lethal effect of ultraviolet irradiation: II. Isolation of thymine photoproducts from the nucleic acids of Streptococcus faecalis

Helge L. Günther, William H. Prusoff

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Year:

1967

Language:

english

File:

PDF, 609 KB

english, 1967

24

The effect of 5-iodo-2′-deoxyuridine and its mono- and triphosphates on some enzymes concerned with the biosynthesis of DNA in cell-free extracts of murine neoplastic cells

Y.S. Bakhle, William H. Prusoff

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Year:

1969

Language:

english

File:

PDF, 403 KB

english, 1969

25

Deoxyribonucleotide metabolism in herpes simplex virus infected HeLa cells

Yung-Chi Cheng, Barry Goz, William H. Prusoff

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Year:

1975

Language:

english

File:

PDF, 703 KB

english, 1975

26

The incorporation of 5-iodo-5′-amino-2′,5′-dideoxyuridine and 5-iodo-2′-deoxyuridine into herpes simplex virus DNA. Relationship between antiviral activity and effects on DNA structure

Paul H. Fischer, Ming S. Chen, William H. Prusoff

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Year:

1980

Language:

english

File:

PDF, 632 KB

english, 1980

27

Unusual structural features of 2′,3′-dideoxycytidine, an inhibitor of the HIV (AIDS) virus

George I. Birnbaum, Tai-Shun Lin, William H. Prusoff

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 459 KB

english, 1988

28

5-Bromo-2'-deoxycytidine (BCDR)-II. Studies with murine neoplastic cells in culture and in vitro

John W. Cramer, William H. Prusoff, Arnold D. Welch

Journal:

Biochemical Pharmacology

Year:

1961

Language:

english

File:

PDF, 429 KB

english, 1961

29

5-Bromo-2'-deoxycytidine (BCDR)-I. Studies on metabolism in vitro and in mice

William H. Prusoff, John W. Cramer, Ming Y. Chu, Arnold D. Welch

Journal:

Biochemical Pharmacology

Year:

1961

Language:

english

File:

PDF, 255 KB

english, 1961

30

Studies on the biochemical pharmacology of 5-IODO-2'-deoxycytidine in vitro and in vivo

John W. Cramer, William H. Prusoff, Arnold D. Welch, Alan C. Sartorelli, Irvine W. Delamore, Carl F. Von Essen, Pauline K. Chang

Journal:

Biochemical Pharmacology

Year:

1962

Language:

english

File:

PDF, 643 KB

english, 1962

31

Studies on the metabolism of thymine and 6-azathymine

Raymond A. Gaito, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1962

Language:

english

File:

PDF, 983 KB

english, 1962

32

Effect of 5-iodo-2'-deoxyuridine on the biosynthesis of phosphorylated derivatives of thymidine

Irvine W. Delamore, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1962

Language:

english

File:

PDF, 1019 KB

english, 1962

33

Some biological and biochemical properties of 5-iodocytosine

Y.S. Bakhle, William A. Creasey, Alan C. Sartorelli, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1964

Language:

english

File:

PDF, 785 KB

english, 1964

34

Effect of thymine ribonucleoside on the metabolism of 125I-5-iodo-2′-deoxyuridine

Brian W. Fox, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1966

Language:

english

File:

PDF, 594 KB

english, 1966

35

Nucleoside analogs with antiviral activity

William H. Prusoff, David C. Ward

Journal:

Biochemical Pharmacology

Year:

1976

Language:

english

File:

PDF, 940 KB

english, 1976

36

Synergistic effect of 5′-amino-5′-deoxythymidine and 5-iodo-2′-deoxyuridine against herpes simplex virus infections in vitro

Paul H. Fischer, Jung J. Lee, Ming S. Chen, Lin Tai-Shun, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1979

Language:

english

File:

PDF, 252 KB

english, 1979

37

Reversal of the cytotoxicity of 3′-amino-3′-deoxythymidine by pyrimidine deoxyribonucleosides

Paul H. Fischer, Lin Tai-Shun, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1979

Language:

english

File:

PDF, 518 KB

english, 1979

38

Specific protection against the cytotoxicity of a new class of nitrosoureas by pyrimidine deoxyribonucleosides

Paul H. Fischer, Lin Tai-Shun, Ming S. Chen, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1979

Language:

english

File:

PDF, 862 KB

english, 1979

39

Studies of the effects of 5-iodo-2′-deoxyuridine on the formation of adenovirus type 2 virions and the synthesis of virus-induced polypeptides

June Kan-Mitchell, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1979

Language:

english

File:

PDF, 1.28 MB

english, 1979

40

Effect of 3'-amino-3'-deoxythymidine on L1210 and P388 leukemias in mice

Lin Tai-Shun, Paul H. Fischer, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1982

Language:

english

File:

PDF, 279 KB

english, 1982

41

Measurement of carbamoylating activity of nitrosoureas and isocyanates by a novel high-pressure liquid chromatography assay

William F. Brubaker Jr., Zhao Hui-Ping, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 690 KB

english, 1986

42

Antiviral activity of 2′,3′-dideoxycytidin-2′-ene (2′,3′-dideoxy-2′,3′-didehydrocytidine) against human immunodeficiency virus in vitro

Tai-Shun Lin, Raymond F. Sohinazi, Ming S. Chen, Elaine Kinney-Thomas, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 510 KB

english, 1987

43

Potent and selective in vitro activity of 3' -deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus

Lin Tai-Shun, Raymond F. Schinazi, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 315 KB

english, 1987

44

Effect of incorporation of 5-iodo-2′-deoxyuridine into HSV-1 DNA on virion sensitivity to ultraviolet light

Marcia L. Zucker, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 614 KB

english, 1987

45

Initial studies on the cellular pharmacology of 3'-deoxythymidin-2'-ene (d4t): A potent and selective inhibitor of human immunodeficiency virus

E.Michael August, Maria Elena Marongiu, Lin Tai-Shun, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 331 KB

english, 1988

46

Studies on the inhibition of mitochondrial DNA replication by 3′-azido-3′-dhoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication

Melvin V. Simpson, Craig D. Chin, Sue A. Keilbaugh, Tai-shun Lin, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 368 KB

english, 1989

47

Effect of 3'-deoxythymidin-2'-ene (d4T) on nucleoside metabolism in H9 cells

Maria Elena Marongiu, E.Michael Auoust, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 700 KB

english, 1990

48

Effect of ultraviolet light on DNA structure in 5-iodo-2′-deoxyuridine-substituted HSV-1 DNA

Thomas G. Wood, Maria Elena Marongiu, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 481 KB

english, 1991

49

The pc12 cell as a model for studies of the mechanism of induction of peripheral neuropathy by anti-HIV-1 dideoxynucleoside analogs

Sue A. Keilbaugh, William H. Prusoff, Melvin V. Simpson

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 306 KB

english, 1991

50

Inhibition of poly(ADP-ribose)polymerase activity by nucleoside analogs of thymidine

Arman D. Pivazyan, Evelyn M. Birks, Thomas G. Wood, Lin Tai-Shun, William H. Prusoff

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 875 KB

english, 1992

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